急性脑血管病患者血浆t-PA、PAI-1活性测定及意义

The plasma level of t-PA、PAI-1 and P/t in the patients with acute cerebrovascular disorders

目的研究急性脑血管病(脑梗死和脑出血)患者的血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物(PAI-1)的活性变化及临床意义。方法采用酶联免疫吸附法测定67例急性脑梗死和53例脑出血患者的t-PA和PAI-1的活性,并计算P/t值,与50例正常对照组进行比较分析。结果急性脑血管病组患者急性期(7d内)血浆t-PA及PAI-1活性均升高,与正常对照组比较有显著性差异(P<0.05);脑梗死组P/t值与正常对照组比较有显著性差异(P<0.05);脑出血组P/t值与正常对照组比较无显著性差异(P>0.05)。结论脑梗死和脑出血患者急性期血浆P/t改变不同;脑梗死患者急性期P/t降低,体内处于相对纤溶亢进状态;脑出血患者P/t变化不明显,体内凝血纤溶机制相对平衡;P/t值可以更好地反映血液中的纤溶活性。

Objective To study the plasma level of t-PA.PAI-1 and P/t in the patients with acute cerebrovascular disorders. Methods The level of t-PA and PAI-1 were tested with ELISA. The level of t-PA and PAI-1 were compared among 67 cases of patients with acute cerebral infarction （CI）. 53 cases of patients with cerebral hernorrhage （CH） group and 50 healthy persons （contral group）. Results The concentration of plasma t-PA and PAI-1 were higher in acute cerebral infarction （CI） group and cerebral hemorrhage （CH） group than in contral group （P〈 0. 05）. The P/t showed signincant difference between CI group and contral group （P〈0. 05） ; no signincant difference between CH group and contral group （P〈0. 05）. Conclusion; The P/t might represent the fibriuolytic activity. The P/t was inverse proportion to the fibriuolytic activity. The relative increase of fibriuolytic activity was the feature of the patients with acute CI; and relative balance of fibriuolytic activity with acute CH.