脑梗死急性期降压治疗对预后的影响

The effect of blood pressure lowering treatment during the acute period of ischemic stroke on stroke outcome

目的研究脑梗死急性期降压及在不同时间进行降压治疗对患者近期预后的影响。方法据发病后是否降压及进行降压的时间,将198例急性脑梗死患者分为6组,观察各组患者神经功能缺损程度及心脑血管事件的再发生率和病死率。结果在发病后进行降压治疗的患者中其心脑血管事件再发率和病死率明显低于未降压组(P<0.01);3d后降压组患者神经功能恢复的程度明显好于未降压组(P<0.01)。结论降压治疗可以降低患者心脑血管事件的发生率和病死率;3d后进行降压治疗的患者神经功能恢复明显要好。

Objective To evaluate the relatienship between blood pressure lowering in different time and stroke outcome in acute ischemic stroke patients with hypertension. Methods 198 patients with acute ischemic stroke were divided into 6 groups. Patient＇s neurological functional deficit was scored by National Institutes of Health Stroke Scale （NIHSS）, the incidence rate of cadio-or cerebral vessels event recurrence and mortality were observed at different time. Results Patients with blood pressure lowering treatment had more significant benefit than the patients without blood pressure lowering treatment（P〈0.01 ）. The incidence rate of cadio-or cerebral vessels recurrent events and mortality in patients with blood pressure lowering treatment was much higher （P〈0.01）. Conclusions With the treatment, the mortality and the incidence rates of cadio-or cerebral vessels recurrent events are decreased. Blood pressure lowering treatment after 3 days of ischemic stroke is associated with better outcome.