缺氧诱导因子-1α在结肠肿瘤中的表达及意义

Expression and significance of hypoxia inducible factor-1α in colon carcinoma

目的探讨缺氧诱导因子-1α（HIF-1α）在结肠肿瘤中的表达及其意义。方法采用免疫组织化学方法，对30例结肠癌患者癌组织及癌旁组织、10例结肠腺瘤患者腺瘤组织中H1F-1α的表达情况进行检测，并分析HIF-1α表达与结肠癌临床病理特征之间的关系。结果HIF-1α阳性率在结肠癌和结肠腺瘤组织中分别为73．3％（22／30）和10．0％（1／10），而在癌旁组织中无表达（P〈0．05）。结肠癌组织中HIF．1et的表达水平与患者性别、年龄、病理组织学类型及分化程度无关（P〉0．05），而与区域淋巴结转移状况及Dukes分期密切相关（P〈0．05）。结论HIF-1α过度表达与结肠癌的浸润、转移密切相关，可能作为判断预后的重要指标。

Objective To explore expression and significance of hypoxia inducible factor-1α （HIF-1α） in colon carcinoma. Methods Immunohistochemical method was used to detect the expression of HIF-1 α in carcinoma tissues from 30 cases with colon carcinoma and in adenoma tissues from 10 with colon adenoma. In the meantime, relationship of HIF-1α expression with clinical pathological characteristics of colon carcinoma was analyzed. Results The positive rate of HIF-1α expression in colon cancer was 73.3% （22/30）, obviously higher than 10.0% （1/10） in colon adenoma but none in normal tissues （ P 〈0.05）. HIF-1α expression in colon carcinoma tissues had no relation with sex, age, pathohistological type and differentiation degree of colon carcinoma （ P 〉 0.05 ） but closely related with state of lymph node metastasis and Dukes staging （ P 〈0.05 ）. Conclusions The overexpression of HIF-1α is highly correlated to the invasion and metastasis of colon carcinoma and may be an important prognostic index.