长托宁与阿托品治疗有机磷中毒效果的对比分析

The Analysis of Curative Effect between Changtuoning and Atropine on Cases with Organophosphorus Poisoning

目的观察长托宁与阿托品治疗急性有机磷农药中毒的效果。方法将急性有机磷农药中毒患者随机分为长托宁治疗组与阿托品治疗对照组,采用推荐剂量按轻、中、重分组并治疗,并对其治疗效果进行比较。结果长托宁对不同中毒程度患者毒蕈碱样症状的控制疗效确实可靠,与对照组相比,达到阿托品化时间无明显差异(p>0.05),但血清组织释放酶峰值、住院时间、住院费用及用药过量发生率均显著降低(p<0.05),尤其是给药次数极显著地减少(p<0.001),对有机磷中毒昏迷病人昏迷时间及因胆碱能危象所致呼吸衰竭病人呼吸恢复时间均明显缩短(p<0.05)。结论长托宁是救治急性有机磷农药中毒较为理想的抗胆碱药。

Objective To observe the effect of the new cholinolytic Changtuoning and Atropine on the treatment of acute organophospho- rus pesticides poisoning. Methods Patients with acute organophosphorus pesticides poisoning were divided randomly into two groups. The cases in Group I were treated with Changtuoning and the cases in Group II with atropine. Different doses were recommended depending on mild, moderate and severe degrees,and therapeutic effects were the compared. Results The effect of Changtuoning was evident in various degrees of poisoning in controlling muscarinic symptoms, compared with the control group, the time needed for the atropinizsation of the treatment group showed no differences （p 〉 0. 05 ）. The peak values of serum enzyme, course of disease, hospitalization expense and incidence of overdose in the treatment group differed markedly（p 〈 0. 05 ） ,from the control group especially the times of administrating drugs（p 〈 0. 001 ）. The course of organophosphoric coma and respiratory failure which caused by cholinergic crisis shortened markedly too （p 〈 0. 05 ）. Conclusion Changtuoning is an ideal cholinolytic to acute organophosphorus pesticide poisoning.