不同浓度抗菌素对血浆纤维蛋白原的影响

Influence of Antibiotic Concentration on Plasma Fibrinogen

目的研究4种常用抗菌素的浓度对血浆纤维蛋白原的影响。方法采用凝固法,以加入抗菌素后血浆中纤维蛋白原的凝固时间为指标,观察不同浓度的头孢哌酮钠、氯霉素、乳酸环丙沙星和硫酸庆大霉素对血浆纤维蛋白原的影响。结果随着氯霉素、硫酸庆大霉素和乳酸环丙沙星浓度的降低,血浆中纤维蛋白原的凝固时间延长;而随着头孢哌酮钠浓度的降低,凝固时间反而缩短。随着氯霉素、硫酸庆大霉素、乳酸环丙沙星浓度降低,血浆中纤维蛋白检出率升高;随着头孢哌酮钠浓度降低,血浆中纤维蛋白原检出率亦降低。结论头孢哌酮钠、氯霉素、乳酸环丙沙星、硫酸庆大霉素等抗菌素及其浓度变化对血浆中纤维蛋白原的凝固时间和检出率有显著影响。

Objective To explore the influence of concentrations of common antibiotics on the fibrinngen in plasma. Methods Add the cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate at different concentrations into plasma and determine the coagulation time and content of fibrinogen. Results The coagulation time of fibrinogen in plasma increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. However, the detection rate of fibrinogen increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate,but decreased with the decreasing concentration of cefoperazone sodium. Conclusion The concentrations of cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate showed significant influence on the coagulation time and detection rate of fibrinogen in plasma.