高压氧治疗对176例急性脑梗死患者血浆ET-1含量的影响

The effect of hyperbaric oxygen therapy on plasma ET-1 levels in 176 patients with acute cerebral infarction

目的探讨高压氧(HBO)治疗对急性脑梗死患者血浆ET-1含量及临床疗效的影响。方法急性脑梗死患者176例,分成HBO治疗组97例和常规治疗组79例,两组均给予常规治疗,HBO治疗组在发病第3天行HBO治疗,共2个疗程,分别于每个疗程结束后测定血浆ET-1含量,第2个疗程结束后行疗效评定。结果急性脑梗死病后血浆ET-1含量明显增高,HBO治疗1个疗程后血浆ET-1含量明显降低,与常规治疗组比较差异有统计学意义(P<0.01)。第2个疗程末,两组比较血浆ET-1含量差异无统计学意义(P>0.05),HBO治疗组治愈率+显效率明显优于常规治疗组,两组比较差异有统计学意义(P<0.05)。结论HBO治疗急性脑梗死可明显降低血浆ET-1含量,对急性脑梗死有较好的治疗作用。

Objective To explore the effect of hyperbaric oxygen （HBO） on the plasma ET-1 levels and its clinical therapeutic effect on acute cerebral infarction patients. Methods One hundred and seventy-six cases of acute cerebral infarction patients were divided into HBO treatment group （97 cases） and conventional therapy group （79 cases）. Both groups were given conventional therapy. The HBO treatment group were given two courses of HBO treatment from the third day after the onset of infarction. The contents of plasma ET-1 were detected and the therapeutic effect were evaluated after two courses of HBO treatment. Results The contents of plasma ET-1 were increased after acute cerebral infarction. After one course of HBO treatment, the ET-1 contents in the HBO group were significantly decreased, compared with those of the conventional therapy group （P 〈 0.01 ） ; after two courses of treatment the difference was not significant （P 〉 0. 05 ）. The healing rate and effective rate of the HBO treatment group were significantly higher than those of the conventional treatment group （P 〈0.05 ）. Conclusions HBO treatment could obviously decrease the plasma ET-1 contents and had good therapeutic effect on acute cerebral infarction.