摘要
芳基重氮化合物在铜盐催化下与烯胺反应,并不产生预期的氨基环丙烷产物,而高产γ-酮酯。改变重氮化合物的结构,产率影响不大。通过分析,发现反应的最初产物是取代的烯胺,该烯胺中间体在硅胶柱层析过程中发生水解,生成γ-酮酯为最终产物。
The reaction of aryldiazoacetates with enamines catalyzed by copper and rhodium complexes provided γ-ketoesters in good yields, the property of aryldiazoacetates showed slight effect on the results of this reaction. Careful analysis of the crude reaction mixture revealed a substituted enamine as the primary product, which was hydrolyzed over silica gel to give a γ-keto ester as the final product.
出处
《河北化工》
2006年第11期33-34,共2页
Hebei Chemical Industry
基金
江苏省重点实验室开放基金(S8109104)
