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基质金属蛋白酶-9与脑梗死的关系 被引量：6

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摘要 近年研究发现炎症在动脉粥样硬化及脑梗死中发挥重要作用,炎性标志物基质金属蛋白酶-9(MMP-9)可降解细胞外基质,削弱纤维帽的结构,增加动脉粥样硬化斑块的不稳定性,加速斑块裂解,促进斑块破裂和血栓形成。脑梗死时MMP-9过度表达可破坏血-脑脊液屏障并形成脑水肿,在继发性脑出血和脑损伤过程中发挥了关键性作用。
作者 付锦 张雪梅
机构地区 哈尔滨医科大学附属第二临床医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 2007年第3期170-172,共3页 Chinese Journal of Neuroimmunology and Neurology
基金 黑龙江省教育厅科学技术研究基金资助项目(10541111)
关键词 基质金属蛋白酶-9 脑梗死 动脉粥样硬化
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献13

  • 1Loftus IM,Naylor AR,Bell PR,et al.Plasma MMP-9:a marker of carotid plaque instability[J].Eur J Vasc Endovasc Surg,2001,21:17-21.
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  • 8蔡斌,许国英,林元相.基质金属蛋白酶-9与脑缺血[J].中华神经医学杂志,2005,4(12):1284-1285. 被引量：8
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二级参考文献18

  • 1章应慧,屈伸.失巢凋亡[J].医学分子生物学杂志,2005,2(1):1-4. 被引量：18
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  • 3Asahi M,Asahi K,Jung J,et al.Role for matrix metalloproteinase 9 after focal cerebral ischemia:effects of gene knockout and enzyme inhibition with BB-94[J].J Cereb Blood Flow Metab,2000,20(12):1681-1689.
  • 4Asahi M,Wang X,Mori T,et al.Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia[J].J Neurosci,2001,21(19):7724-7732.
  • 5Castellanos M,Leira R,Serena J,et al.Plasma metalloproteinase-9concentration predicts hemorrhagic transformation in acute ischemic stroke[J].Stroke,2003,34(1):40-46.
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共引文献7

同被引文献76

引证文献6

二级引证文献12

中国神经免疫学和神经病学杂志
2007年 第3期

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