缺血修饰白蛋白在急性心肌缺血及心肌梗死患者中的诊断意义

Dignostic value of ischemia modified albumin of myocardial ischemia and myocardial infarction

目的探讨缺血修饰白蛋白(ischemia modified albumin,IMA)在心肌缺血与心肌梗死患者中的变化及其临床意义。方法研究60例心肌缺血患者(心肌缺血组),34例急性心肌梗死患者(心肌梗死组)及52例健康个体(对照组),分别测定IMA、肌钙蛋白I(cTnI)及肌酸激酶同工酶(CK-MB),对结果进行统计学分析。结果健康对照组、心肌缺血组、心肌梗死组,其IMA区间范围分别为(62.0±5.5)ABSU/ml,(78.2±16.6)ABSU/ml,(80.8±20.6)ABSU/ml。心肌缺血组、心肌梗死组其均数区间范围同健康对照组相比,其差别有统计学意义。但心肌缺血和心肌梗死组之间差别无统计学意义。结论IMA是心肌缺血的敏感指标,区分可逆性缺血与梗死的能力较差。

Objective To observe the change and the clinical significance of isehemia modified albumin（IMA） level in myocardial ischemia and acute myocardial infarction patients. Methods IMA, troponin I （cTnI） and CK-MB were measured in 60 cases of myocardial ischemia（myocardial ischemia group）,34 acute myocardial infarction patients （AMI group） and 52 controls. Individual condition in the patients （target = 94） with acute chest pain or chest suffocating and healthy people was observed ,and the results were analysed by statistic method. Results The mean of IMA of healthy people,myocardial ischemia and AMI patients were （62.0±5.5） ABSU/ml, （78.2± 16.6） ABSU/ml, （80.8±20. 6） ABSU/ml, respectively. Myocardial ischemia and AMI patients had a high distinction from control group,but IMA was a poor discriminator between the former two groups. Conclusion These preliminary results suggest that IMA is a good biomarker for the assessment of myocardial ischemia but a poor discriminator between ischemia patients with and without MI.