摘要
为探讨血清IgA-纤维连接蛋白(FN)聚合物在IgA肾病中的辅助诊断价值,对91例IgA肾病、14例过敏性紫癜性肾炎、117例非IgA肾脏病、24例非肾脏病及234例健康人采用ELISA方法检测了血清中IgA-FN聚合物水平。结果显示,IgA肾病血清该聚合物水平及阳性率(61.5%)显著高于狼疮性肾炎(30.8%)、其他非IgA肾脏病(8.8%)、非肾脏病(0.0%)及健康人群(5.1%)(P<0.05),但与过敏性紫癜性肾炎组(42.9%)差异无显著性(P>0.05)。提示该聚合物对IgA肾病具有一定的辅助诊断价值。但因在过敏性紫癜性肾炎及狼疮性肾炎时也有较高的阳性率,应注意鉴别。
In order to demonstrate the diagnostic value of serum IgA fibronectin (FN) aggregates in IgA nephropathy, serum samples from 91 patients with IgA nephropathy, 14 patients with Henoch Schonlein purpura, 117 patients with non IgA nephritis, 24 random in patients and 234 normal controls were examined for IgA FN aggregates by using ELISA. The results showed that the level of IgA FN aggregates increased markedly in the serum of patients with IgA nephropathy and 61.5% of them reached the positive standard. Only 8.8% of the patients with non IgA nephritis, none of the in patients with non renal diseases and 5.1% of the normal controls were beyond the positive criteria. But the level of IgA FN aggregates were also elevated in the serum of patients with Henoch Schonlein purpura and lupus nephritis. These data indicate that serum IgA FN aggregates may be useful in the diagnosis of IgA nephropathy, but Henoch Schonlein purpura and lupus nephritis should be ruled out.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第2期83-86,共4页
Chinese Journal of Internal Medicine