蛋白质组学中基质辅助激光解吸电离的基质研究进展

Recent Development of Matrix Assisted Laser Desorption Ionization Matrix Applied in Proteomics

基质辅助激光解吸电离(MALDI)技术是近年来发展起来的新的质谱离子化技术。本文较为系统地综述了应用于蛋白质组学中的MALDI基质的最新进展以及不同的基质的优缺点及应用范围,并且归纳了其发展趋势。

Matrix assisted laser desorption ionization （MALDI） technology is one of the best mass spectrometry ionization technologies for macro molecules which was developed almost two decades ago. From organic compounds to inorganic materials, there are a lot of matrices that have been developed for MALDI. In this article, we conclude the recent development of MALDI matrix applied in proteomics and discuss its prospect.