摘要
目的:研究肾癌组织中p27kip1和cyclinD1蛋白的表达,探讨其与肾癌生物学特征的内在联系。方法:应用免疫组化S-P法,对53例肾癌及6例正常肾组织中p27kip1和cyclinD1蛋白进行检测。结果:在正常肾组织中p27kip1均呈阳性表达,p27kip1阳性表达率在肾癌不同临床分期,不同病理分级中差异显著(G1~G2:70.00%,G3~G4:27.27%,P<0.05;T1~T2:70.83%,T3~T4:20.69%,P<0.05)。cyclin D1在正常肾组织呈阴性表达,cyclinD1阳性表达率在肾癌不同临床分期,不同病理分级中差异显著(G1~G2:51.35%,G3~G4:27.27%,P<0.05;T1~T2:58.33%,T3~T4:20.69%,P<0.05)。结论:p27kip1和cyclinD1蛋白在肾癌中的表达与肿瘤生物学行为密切相关,p27kip1和cyclinD1在肾癌的发生、发展中起重要作用。
Objective: To evaluate the expressions of p27^kip1 and cyclin D1 in renal cell carcinoma( RCC ),and to explore the association between the biological characteristics of RCC and the expressions of p27^kip1 and cyclin D1. Methods:The expressions of p27^kip1 and cyclin D1 were detected by immunohistochemical S-P method in 53 cases of RCC and 6 normal renal tissues. Results:In normal renal tissues, p27^kip1 was positively expressed and cyclin D1 was negatively expressed. There were significant differences in the positive expression rates of both p27^kip1 and cyclin D1 in renal cell carcinomas of different pathological grades and clinical stages (p27Kip1:G1 to G2 70.00%,G3 to G4 27.27%,T1 to T2 70.83%,T3 to T4 20.69%;cyclin DI:G1 to G2 51.35%,G3 to G4 27.27%,T1 to T2 58.33%,T3 to T4 20.69%;all P〈 0.05 ). Conclusion:The expressions of p27^kip1 and cyclin D1 are closely correlated with biological behavior of RCC. p27^kip1 and cyclin D1 may play important roles in the occurrence and development of RCC.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2007年第2期173-174,共2页
Journal of China Medical University