大鼠扣带回神经元自发放电及神经递质的影响

FEATURES OF SPONTANEOUS DISCHARGE BY GYRUS CINGULI NERVE CELLS OF RATS AND EFFECT ON REUROTRANSMITTERS

采用脑薄片细胞外记录方法 ,观察大鼠扣带回前部神经元自发放电活动的特性 ;以及SP,5- HT,GLU,GABA,NE等神经递质对神经元放电活动的影响 .结果表明 :在 82个扣带回薄片神经元中 ,不规则连续放电的为 51/ 82 ;慢速放电 15/ 82 ;阵发性排放 9/ 82 ;周期性排放 7/ 82 .在神经递质的灌流中 SP有 37/ 6 3;5- HT36 / 6 8;GLU 2 0 / 31的神经元放电活动增加 .GABA有2 4 / 4 2 ;NE2 9/ 4 8的神经元放电活动减少 .此外还发现 ,当 5- HT使神经元放电活动增加时 ,灌流CPD可使放电活动减少 .

By means of recording the cells of cerebral lamellas, the artical reveals the features of spontaneous discharge by rats’front nerve cells of gyrus cinguli, and the effect on the discharge by rourotransmitter perfusions, such as SP,5 HT,GLU,GABA and NE. The result shows that among 82 nerve cells of gyrus cinguli cerebral lamellas, 51 cells dischargs irregularly, 15 slowly, 9 intervally and 7 periodically. In the perfusion of reurotransmitter, on the other hand, there is an increase of discharge in a rate of 37/63 in SP, 36/68 in 5 HT, and 20/31 in GLU,whereas discharges reduce of nerve cells in a rate of 24/42 in GABA and 29/48 in NE. It is observed in addition that when 5 HT increases nerve cells discharge, the perfusion of CPD makes less the discharge activities.