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重组人白细胞介素-11治疗肿瘤化疗致血小板减少18例 被引量：1

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摘要 2004年1月至2006年2月．我科应用重组人白细胞介素-11（rhIL-11）治疗肿瘤化疗致血小板减少患者．现将观察结果报告如下。
作者 刘荣华 唐秀红 商春梅 郝福合
机构地区 山东省淄博矿业集团中心医院内一科 山东省青岛市万杰医院
出处 《实用医学杂志》 CAS 2007年第8期1273-1273,共1页 The Journal of Practical Medicine
关键词 人白细胞介素-11 血小板减少 肿瘤化疗 治疗 重组
分类号 R730.5 [医药卫生—肿瘤]
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参考文献7

  • 1杨波.恶性肿瘤24例化疗后Ⅳ度骨髓抑制的治疗观察[J].实用医学杂志,2004,20(12):1421-1421. 被引量：1
  • 2Goldman S J.Preclinical biology of interleukin 11:a multifunctional hematopoietic cytokine with potent thrombopoietic avtivity[J].Stem Cells,1995,13(5):462-471.
  • 3Paul S R,Bennett F,,Calvetti J A,et al.Molecular cloning of eDNA encoding interleukin 11,a stromal cell-derived lymphopoietic and hematopoietic cytokine[J].Proc Natl Acad Sci U S A,1990,87(19):7512-7516.
  • 4Saitoh M,Taguchi K,Momose K,et al.Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing lewis lung carcinoma cella[J].cancer Chemother Pharmacol,2002,49(2):161-166.
  • 5储大同,徐兵河,宋三泰,毛雪华,焦顺昌,张爱莲.重组人白细胞介素-11预防化疗所致血小板减少的临床研究[J].中华肿瘤杂志,2003,25(3):272-274. 被引量：27
  • 6曹军宁,许立功,吴晴,冯继锋,张沂平,秦凤展,徐建华,战榕,谭清和,吴昌平.重组人白细胞介素-11治疗化疗引起的血小板减少症的II期临床研究[J].中国癌症杂志,2005,15(2):141-144. 被引量：9
  • 7Dykstra K H,Rogge H,Stone A,et al.Mechanism and amelioration of recombinant human interleukin-11 (rhll-11)-induced anemia in healthy subjects[J].J Clin Pharmacol,2000,40(8):880.

二级参考文献18

  • 1Anderson KC. Hematologic complications and blood bank support [A]. Bast RC, Kufl DW, Poliock RE, et al. Cancer Medicine [ M ]. 5 th ed, Hamilton: BC Derker Inc,2000: 2291-2308.
  • 2Goldman SJ. Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity [ J ]. Stem Cells, 1995,13 ( 5 ): 462-471.
  • 3Tepler I, Elias L, Smith JW 2nd, et al. A randomized placebocontrolled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy [ J ].Blood,1996,87(9): 3607-3614.
  • 4Gordon MS, Mccaskill-Stevens WJ, Battiato LA, et al. A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy [J]. Blood,1996,87(9): 3615-3624.
  • 5Isaacs C, Robert NJ, Bailey FA, et al. Randomized placebocontrolled study of recombinant human interluekin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin [J]. J Clin Oncol,1997,15( 11 ): 3368-3377.
  • 6Kurzrock R, Cortes J,Thomas DA, et al. Pilot study of low-dose interleukin-11 in patients with bone marrow failure [ J ]. J Clin Oncol,2001,19( 21 ) :4165-4172.
  • 7Ault KA, Mitchell J, Knowles C, et al: Recombinant human interleukin eleven ( Neumega rhIL-11 growth factor) increases plasma volume and decreases urine sodium excretion in normal human subjects (Abstr) [ J ]. Blood, 1994,84 ( Suppl1 ): 1994.
  • 8Du X,Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood, 1997, 89: 3897-3908.
  • 9Kaviani MD, Mason LE, Bree AG, et al. Effects of recombinant human interleukin 11 on the activation and morphology of peripheral blood platelets and megakaryocytes in nonhuman primates. Blood,1996,88 (suppl 1):26-29.
  • 10Bruno E,Briddell R, Cooper R, et al. Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells. Exp Hematol, 1991, 19: 378-381.

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实用医学杂志
2007年 第8期

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