眼睑皮肤恶性黑色素瘤早期检测进展

The advances on early detection of eyelid malignant melanoma

眼睑皮肤恶黑瘤发病率低,预后差,在临床及病理上很难与其他肿瘤鉴别。本文回顾了国内外眼睑皮肤恶黑瘤相关基因、肿瘤标志物的文献,发现B-RAF、hTERT、NOS及melan-A均与眼睑皮肤恶性黑色素瘤发生、发展,早期检测相关,有利其鉴别诊断。

Eyelid malignant melanoma is rare but has a grave prognosis. It is very difficult to differentiate eyelid malignant melanoma and other tumors in clinical and pathological. Studies on the correlated genes, tumor markers in eyelid maligo nant melanomas are reviewed in the present paper. The reluits show B-RAF, hTERT, NOS and melan-A contributed to the eyelid malignant melanomas in onset, progress and early detection which are advantageous for differential diagnosis.