SPF级金黄地鼠的主要生物学特性

Characterization of Main Biological Features of SPF Syrian Golden Hamsters

目的测定SPF级金黄地鼠的生物学特性数据,为生物制品的生产、检定及科学研究提供标准化的SPF级金黄地鼠。方法在5周龄、10周龄和30周龄群体中随机抽样20只地鼠,雌雄各半。测定生长发育、繁殖性能、淘汰种鼠干物质及粗脂肪含量、解剖学特性以及血液生理生化指标等生物学特性指标。结果从SPF级金黄地鼠的生长和繁殖特性来看,通过严格的选择和淘汰,SPF级金黄地鼠的生长、繁殖等特性已保留下来,同比原种群得到进一步提高。其体重和主要脏器重量、脏器系数的数据在5、10和30这三个日龄段基本稳定一致,呈现正常的生长规律;该鼠群的血常规、血液生化指标和免疫指标也比较稳定一致,个体间的差异很小。结论本实验测定的SPF级金黄地鼠的主要生物学特性,将为SPF级金黄地鼠进一步标准化提供极其重要的依据。

Objective To obtain data of main biological characteristics in SPF Syrian golden hamsters, and provide standardized animals for production, safety test of biological products and scientific research. Methods 20 Syrian golden hamsters were randomly selected each, males ： females = 1 ： 1, at the age of 5, 10 and 30 weeks, respectively. A number of biological parameters, such as body weight, reproductive performance, blood biochemical data, etc. of the hamsters were measured and analyzed. Results （1） With regard to the growth and reproductive performance, by strict selection and elimination, those properties of SPF Syrian golden hamsters have been preserved, and even improved further. （2） The body weight, most viscera weight and viscera coefficient in 5-, 10- and 30-weeks old Syrian golden hamsters were steadily and consistently increasing, and the data of routine blood examination, blood biochemical and immune indexes were also stable and with little difference among individuals. Conclusions Main biological data of SPF Syrian golden hamsters have been determined by relevant measurements and thus provided an important basis for further standardization of SPF Syrian golden hamsters.