75例血液病骨髓活检病理诊断分析

Pathological diagnosis of hematopathy by bone marrow biopsy: an analysis of 75 cases

目的 探讨骨髓活检石蜡包埋切片在血液病诊断中的意义。方法 收集经临床初诊的各种血液病75例，行常规髂后上棘骨髓活检，石蜡包埋，HE、Gomori、Perls普鲁蓝铁染色及光镜观察。结果 75例中男性30例，女性45例，中位年龄50岁（10-77岁）。其中CIMF2例、AA15例、MDS9例、PCM3例、ALL2例、CML1例、贫血待查22例、全血细胞减少16例、白细胞减少4例、发热待查1例，确诊率61.33％。结论 骨髓活检石蜡包埋切片对从、CIMF、MDS及白血病可直接作出诊断，对贫血及部分血细胞减少性疾病，必须紧密结合临床或BMA方可作出诊断。建,以提高BMB诊断水平。

Objective To investigate the significance of bone marrow biopsy （BMB） and paraffin-embedded section in the diagnoses of hematopathy. Methods Conventional bone marrow biopsy of posterior superior iliac spine was conducted, paraffinembedded sections were stained with HE, Gomori and Prussian blue staining, and oboerved under light microscope. Seventy-five eases （male 30, female 45） of hematopathy were collected. Median age was 50 years （ 10 to 77 years）. Results After bone marrow biopsy and pathological analyses, the final diagnosis was 2 eases of CIMF, 15 AA, 9 MDS, 3 PCM, 2 ALL, 1 CML, 22 anemia with unknown causes, 16 paneytopenia, 4 leukopenia and 1 unknown fever. Confirmed diagnosis rate was 61.33% The bone marrow biopsy and paraffln-embedded section can be used to diagnose AA, CIMF, MDS and leukemia directly. The diagnosis of anemia and partial hypocytosis must be combined closely with clinical data and BMA. Bone marrow biopsy and plastic embedding is suggested to improve the diagnosis of BMB.