大肠癌临床病理特征与血小板增多关系的探讨

Clinical Studies of the Correlation between Clinical Features of Large Intestinal Cancer and Thrombocytosis

目的:探讨大肠癌伴发血小板增多的临床规律及病理特征。方法:分析有完整资料和随访资料的383例大肠癌患者的临床病理资料,其中103例合并血小板增多。结果:大肠癌伴血小板增高103例,占26.9%。血小板增高与大肠癌患者的性别、年龄、病变部位无显著性差异,但与有无梗阻有显著性差异(P<0.005)。血小板增高与大肠癌患者肿瘤的大体形态、直径、分化程度、组织学、病理分期、肠壁浸润深度、淋巴转移均有显著性差异。结论:大肠癌伴血小板增多晚期患者多见,预后差。

Objective： To explore clinical and pathological characteristics of large intestinal cancer with thromboeytosis. Methods： The data of clinical and pathologic characteristics of 383 patients with large intestinal cancer were retrospectively analyzed, among which thronlboeytosis was seen in 103 cases. Results： The large intestinal cancer patients with an increased plalelet count composed 26.9% of the cases （103/383）. There was no correlation between the increased platelet count and the sex, age or diseased region of the patients, but there was a correlation between thromboeytosis and the eondition of the intestinal obstruction （P〈0.0005）. There was also a correlation between thromboeytosis and the tumor＇s macroscopic shape, diameter, degree of differentiation, histologieal grade and pathological stage, infiltrative depth of the intestinal wall and lymphatic metastasis. Conclusion： Increased platelet count is common in patients with advanced stage large intestinal cancer with a poor prognosis.