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血管紧张素Ⅱ受体拮抗剂与心肌梗死的争议和进展

The current controversy and progress of angiotensin Ⅱ receptor blockers and myocardial infarction
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作者 李晓红 陈羽中 李玉明
机构地区 武警医学院附属医院心血管病研究所 武警医学院卫生管理教研室
出处 《武警医学院学报》 CAS 2007年第3期321-324,共4页 Acta Academiae Medicinae CPAPF
关键词 血管紧张素Ⅱ受体拮抗剂 心肌梗死 血管紧张素Ⅱ受体
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献29

  • 1Levy BI.Can angiotensin Ⅱ type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system[J].Circulation,2004,109(1):8-13.
  • 2Julius S,Kjeldsen SE,Weber M,et al.Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine:the VALUE randomised trial[J].Lancet,2004,363 (9426):2022-2031.
  • 3Pfeffer MA,Swedberg K,Granger CB,et al.Effects of candesartan on mortality and morbidity in patients with chronic heart failure:the CHARM-Overall programme[J].Lancet,2003,362(9386):759-766.
  • 4Lewis EJ,Hunsicker LG,Clarke WR,et al.Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes[J].N Engl J Med,2001,345 (12):851-860.
  • 5Senbonmatsu T,Ichihara S,Price E J,et al.Evidence for angiotensin Ⅱ type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload[J].J Clin Inves,2000,106(3):R25-29.
  • 6Ichihara S,Senbonmatsu T,Price E J,et al.Angiotensin Ⅱ type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin Ⅱ-induced hypertension[J].Circulation,2001,104 (3):346-351.
  • 7D' Amore A,Black MJ,Thomas WG.The angiotensin Ⅱ type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin Ⅱ type 1 receptor-mediated hypertrophy[J].Hypertension,2005,46 (6):1347-1354.
  • 8Goldenberg I,Grossman E,Jacobson KA,et al.Angiotensin Ⅱ-induced apoptosis in rat cardiomyocyte culture:a possible role of AT1 and AT2 receptors[J].J Hypertens,2001,19 (9):1681-1689.
  • 9Marchand EL,Der Sarkissian S,Hamet P,et al.Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats[J],Circ Res,2003,92 (7):777-784.
  • 10Sugino H,Ozono R,Kurisu S,et al.Apoptosis is not increased in myocardium overexpressing type 2 angiotensin Ⅱ receptor in transgenic mice[J].Hypertension,2001,37 (6):1394-1398.
武警医学院学报
2007年 第3期

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