代谢综合征病人血浆脂联素水平变化的初步研究

A Preliminary Study of Plasma Adiponectin Levels in Subjects with Metabolic Syndrome

目的探讨代谢综合征(MS)病人血浆脂联素(adiponectin)水平变化及与胰岛素抵抗(IR)的关系。方法筛选MS病人30例及与其年龄、性别相匹配的健康成年人20例为对照组。采用酶联免疫吸附法(ELISA)检测血浆脂联素水平,用HOMA-IR评估IR程度。结果MS组与对照组比较,血浆脂联素水平显著降低[(5.15±2.54)μg/mL与(10.28±5.50)μg/mL,P<0.01];MS组的HOMA-IR指数显著高于对照组[(3.21±1.14)与(1.79±0.98),P<0.05];在MS组,脂联素与体重指数(BMI)、腰围(WC)、三酰甘油(TG)及HOMA-IR呈负相关,与高密度脂蛋白胆固醇(HDL-C)呈正相关,相关系数r值分别为-0.489,-0.548,-0.429,-0.453及0.426(P<0.05)。结论代谢综合征病人血浆脂联素较正常人群降低,且其水平降低可能与IR有关。

Objective To investigate adiponectin levels and the relationship between plasma adiponectin levels and insulin resistance （IR） in subjects with metabolic syndrome （MS）. Methods Thirty subjects with MS and 20 age- matched normal subjects were enrolled. Plasma adiponectin levels were measured by ELISA. IR was evaluated by HOMA- IR. Results Plasma adiponectin levels in MS group were significantly lower than that in controls [ （5.15 ± 2.54 ）μg/mL vs （10.28 ±5.50） μg/mL （P 〈 0.01 ）. HOMA- IR in MS group was significantly higher than that in controls[ （3.21 ± 1.14） vs （ 1.79 ± 0.98, P 〈 0.01 ）. Adiponectin was inversely associated with BMI, WC, TG, HOMA- IR and positively associated with HDL - C （ r = - 0. 489, - 0. 548, - 0. 429, - 0. 453 and 0. 426, respectively, P 〈 0.05 for all correlations）. Conclusion Plasma adiponectin levels in MS subjects were significantly lower than that in controls and lowered plasma adiponectin levels might be associated with IR.