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基质细胞联合细胞因子对脐血CD133阳性细胞体外扩增和粘附分子表达的影响 被引量：1

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摘要 CD133是新近发现的造血干细胞表面标志，众多的实验表明，脐血CD133^＋细胞能在体外得以扩增，我们选用脐血单个核细胞（MNC）作为培养的起始细胞，应用实验室已经建立的胚胎骨髓基质细胞联合细胞因子的造血细胞体外培养体系，研究脐血MNC中CD133^＋细胞在此培养体系的扩增效果，并检测CD133^＋细胞表面粘附分子CD44、CD62L的表达率，评估扩增后的脐血CD133^＋细胞的归巢能力。
作者 卢丽娜 毛平 曾进龙 王彩霞 杜庆华
机构地区 广州医学院附属广州市第一人民医院
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2007年第4期247-248,共2页 Chinese Journal of Organ Transplantation
基金 广东省科技计划项目基金（B30202） 广州市科学技术局科技攻关重点项目基金（200222-E0241）
关键词 CD133^+细胞 脐血单个核细胞 细胞体外扩增 骨髓基质细胞 细胞因子 粘附分子表达 粘附分子CD44 细胞表面标志
分类号 R686 [医药卫生—骨科学]
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参考文献13

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二级参考文献21

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共引文献8

同被引文献16

  • 1毛平,许力,莫文健,应逸,许艳丽,林秀梅.不同细胞因子组合对人脐血单个核细胞体外扩增及CD49d和CXCR4表达的影响[J].中国实验血液学杂志,2006,14(2):318-321. 被引量：7
  • 2毛平,彭盘俐,许力.人脐血单个核细胞体外扩增后植入NOD/SCID小鼠重建多系造血[J].中华器官移植杂志,2006,27(4):231-234. 被引量：13
  • 3毛平,许力,应逸,许艳丽,莫文健,林秀梅,王彩霞.干细胞因子与FLT3配基协同促巨核细胞生成因子对脐血单个核细胞的扩增及造血重建功能的影响[J].中华医学杂志,2006,86(24):1718-1721. 被引量：1
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  • 8Lee YH, Lee YA, Noh JT, et al.Homing-associated cell adhesion molecules and cell cycle status on the nucleated cells in the bone marrow, mobilized peripheral blood and cord blood. J Korean Med Sci 2004;19(4):523-528
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二级引证文献1

中华器官移植杂志
2007年 第4期

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