加味五子衍宗颗粒对轻度认知障碍患者记忆功能及血清β淀粉样蛋白的影响

The effect of Jiawei Wuzi Yanzong Particle on memory ability and level of serum beta-amyloid protein of mild cognitive impairment patients

目的观察加味五子衍宗颗粒对轻度认知障碍(MCI)患者记忆功能及血清β淀粉样蛋白(Aβ1-28)的影响。方法筛选36例MCI患者,采用随机双盲分组,分为加味五子衍宗颗粒治疗组(18例)和安慰剂对照组(18例),服药3个月,观察用药前后记忆功能及血清β淀粉样蛋白(Aβ1-28)的变化。另设20例正常人对照组。结果MCI的记忆商(MQ)较正常对照组明显降低(P<0.01),血清β淀粉样蛋白的含量较正常对照组明显升高(P<0.05)。用药后加味五子衍宗颗粒治疗组的MQ较其用药前明显提高(P<0.01),且较安慰剂对照组治疗前后MQ的差值有明显提高(P<0.05),治疗组较安慰剂组血清β淀粉样蛋白的含量明显降低(P<0.05)。结论加味五子衍宗颗粒能改善MCI患者记忆功能及血清β淀粉样蛋白的代谢功能,对延缓MCI的发展具有一定的临床意义。

Objective To observe the effect of Jiawei Wuzi Yanzong Particle （JWYP） on memory ability and level of serum betaamyloid（AI3）l-28 in mild cognitive impaired （MC]） patients. Methods 36 MCI patients selected according to international received criteria at present were randomly divided into two groups in double blind method, JWYP group （ 18 cases） and placebo control group （ 18 cases）, for treatment course of 3 months, and 20 healthy people were chosen as controls. The changes in memory ability and levels of serum Aβ1-28 before and after medication were observed. Results Before treatment, MCI patients had significantly lower memory quotient （MQ） （ P 〈 0. 01 ） and higher level of serum Aβ1-28 （ P 〈 0.05 ） than healthy controls. After treatment, there was remarkable increase in MQ （ P 〈 0. 01 ） than that before treatment in JWYP group. The difference value before and after treatment in JWYP group was higher than that in placebo control group （ P 〈 0. 05 ）. Serum Aβ1-28 level （ P 〈 0. 05 ） in JWYP group was obviously lower than that in placebo control group（ P 〈 0. 05）. Conclusions JWYP could improve MCI patients＇ memory ability and metabolic function of serum Aβ1-28, which plays a clinical significance in delaying MCI development.