多源偶极子定位在癫痫发作间歇期的应用研究

Study of multiple source dipole imaging for pre-operation of the epileptogenic discharge in patients with intractable epilepsy

目的 研究多源偶极子定位法对癫痫灶的定位研究价值及准确度。方法 对50例顽固性癫痫病人，通过术前在发作间期采用多源偶极子定位瘸源位置，术中皮层电极（ECoG）、深部电极确定痫灶范围，并进行手术处理，对比偶极子定位的准确性并进行术后随访。结果对颞叶癫痫，偶极子定位与ECoG及深部电极基本一致，对额叶、顶叶、枕叶癫痫，误差约10～15mm，随访8-36个月，50例中，36例无发作，9例发作出少于75％。3例发作少于50％，2例发作同术前。结论间歇期头皮脑电多源偶极子定位方法准确可靠，相当于有创性电生理定位意义。

Objective To investigate the feasiability dipole multiple source imaging for presurgical localization of the epileptogenic zone in patients with intractable epilepsy. Methods To compare the accuracy of the localization of epileptogenic zone by pre-operative scalp EEG multipie sources imaging and ECoG During operation in 50 patients with intractable epilepsy Results For localization of the epileptogenic zone multiple dipoles source imaging has not error in temporal lob epilepsy and has an error with a tolerance of less than 15 cm in extra-temporal lob epilepsy. Conclusion The localization of epileptogenic zone by source imaging from a scalp EEG is correct better and it can be used and insteade of the invasive recordings in pre-operative localization of the epileptogenic zone for intractable epilepsy.