梗阻性黄疸围手术期细胞免疫功能障碍发生机制研究进展

Advance on the mechanisms of cellular immune dysfunction during the perioperative stage of obstructive jaundice patients

细胞免疫功能障碍是梗阻性黄疸围手术期并发症发生率较高的重要原因.本文通过回顾近20a的研究资料,对梗阻性黄疸围手术期细胞免疫功能障碍的发生机制进行分析,认为高胆红素、高胆汁酸、内毒素血症、原发病、手术及麻醉都可能与之相关.

The dysfunction of cellular immunity is a significant cause of the high complication incidence during the perioperative stage of obstructive jaundice patients. Through reviewing the research data in the past 20 years, we try to analyze mechanisms of cellular immune dysfunction during this stage and consider that it is correlated with bilirubin toxicity, bile acid toxicity, endotoxemia, primary disease, operation and anesthesia.