清热化瘀汤对老年胃食管反流病患者血清超氧化物歧化酶及脂质过氧化物的影响

Effect of Qingre Huayu decoction on the contents of superoxide dismutase and lipid peroxide in old patients with gastroesophageal reflux disease

目的:观察清热化瘀汤治疗对老年胃食管反流病患者血清超氧化物歧化酶(SOD)及脂质过氧化物(LPO)的影响.方法:将160例老年胃食管反流病患者随机分为观察组(n=80)和对照组(n=80),分别给予内服清热化瘀汤和口服西药治疗.治疗前后分别检测血清SOD(双抗体法)和LPO(硫代巴比妥酸法)的含量,并用t检验方法进行统计学分析.结果:治疗后两组SOD含量均呈上升趋势,但观察组明显上升,且接近正常值水平,与对照组比较有显著性差异(26.01±2.56 kU/L vs 23.02±2.54 kU/L,P<0.05);治疗后两组LPO含量均呈下降趋势,但观察组明显下降,且接近正常值水平,与对照组比较差异显著(4.19±0.52 mol/L vs 4.96±1.13 mol/L,P<0.05).结论:清热化瘀汤治疗胃食管反流病,具有明显改善自由基代谢紊乱的作用.

AIM： To observe the effect of Qingre Huayu decoction （QHD） on the contents of superoxide dismutase （SOD） and lipid peroxide （LPO） in old patients with gastroesophageal reflux disease （GERD）. METHODS： A total of 160 cases of old patients with GERD were randomly divided into group A （n = 80） and B （n = 80）, treated with QHD and Western medicine, respectively. The serum contents of SOD and LPO before and after treatment were detected by double antibody method and thiobarbituric acid reaction, respectively. The results were analyzed with t-test statistically. RESULTS： After treatment, SOD content was increased in both groups, but got close to the normal level in group A. There was significant difference between group A and B （26.01 ± 2.56 kU/L vs 23.02 ± 2.54 kU/L, P 〈 0.05）. However, the content of LPO was decreased in both groups after treatment, and there was also significant difference between group A and B （4.19 ± 0.52 mol/L vs 4.96 ± 1.13 mol/L, P 〈 0.05）. CONCLUSION： QHD has a favorable effect in the treatment of GERD by ameliorating the metabolic disorder of free radicals.