手术联合腹腔温热灌注化疗治疗Ⅲ_b,Ⅳ期胃癌的疗效观察

Observations on therapeutic outcome of operation combined with hyperthermic intraperitoneal lavage chemotherapy in treatment of stages Ⅲ_b and IV gastric cancer

目的探讨Ⅲb,Ⅳ胃癌术中、术后腹腔温热灌注化疗对其术后腹膜转移和生存率的影响。方法对比研究胃癌单纯手术(对照组,31例)和手术加术中、术后腹腔温热灌注化疗(化疗组,50例)的临床资料。结果化疗组2年及3年生存率高于对照组,腹腔2年及3年复发率低于对照组。结论胃癌术中、术后腹腔温热灌注化疗对防治肿瘤腹膜转移,提高生存率有重要意义。

Objective To discuss the effect of intra-operative and post-operative hyperthermic intraperitoneal lavage chemotherapy for Ⅲb and Ⅳ gastric cancer on post-operative peritoneal metastasis and survival rate. Methods The clinical data of 31 cases of gastric cancer （ control group ） who underwent operation only and 50 cases （chemotherapy group ） who receved operation combined with intra-operative and post-operative hyperthermic intra-peritoneal lavage chemotherapy were comparatively studied. Results The survival rate of control group after 2 years and 3 years was lower than that of the chemotherapy group, and the intraperitoneal recurrence rate of control group after 2 years and 3 years was higher than that of chemotherapy group. Conclusions Intra-operative and pest-operative hyperthermic intraperitoneal lavage chemotherapy for gastric cancer has important significance in prevention and treatment of peritoneal metastasis and can improve survival rate.