大肠癌患者外周血淋巴细胞粘着斑激酶表达的临床意义

Expression of focal adhesion kinase in peripheral blood of patient with colorectal cancer

目的探讨大肠癌患者外周血淋巴细胞粘着斑激酶(FAK)的表达及其临床意义。方法结果结论方法应用流式细胞仪(flow cytometry,FCM)检测40例大肠癌患者及20例正常人外周血淋巴细胞中FAK的表达。结果大肠癌患者外周血淋巴细胞FAK阳性表达率为60.0%,与正常人(25.0%)比较,差异有显著性意义(P<0.05)。并且外周血淋巴细胞FAK表达与大肠癌临床分期、组织学分化程度、淋巴转移有关。结论大肠癌患者外周血淋巴细胞FAK异常表达与荷瘤状况有关,对大肠癌的早期诊断、临床分期、组织学分型、淋巴转移的预测等可能有一定帮助。

Objective To investigate the expression of focal adhesion kinase in peripheral blood of colorectal cancer and its clinical significance. Methods Focal adhesion kinase in peripheral blood was determined with flow cytometry in 40 cases of colorectal cancer and 20 cases of control group. Results The positive rate of focal adhesion kinase in colorectal cancer group was 60.0% and in control group was 25.0% , respectively （P 〈 0.05）. Mean value of focal adhesion kinase expression was high in cases with cancers and was related to clinical stage, degree of histological differentiation, and lymphatic metastasis. Conclusions Focal adhesion kinase expression in human peripheral blood lymphocytes may be related with the tumor load statue, and can be used as an index for surveillance and screening of colorectal cancer high risk population.