摘要
目的:检测67例胆囊癌、10例胆囊腺瘤及癌旁粘膜的p53蛋白表达,分析其与肿瘤组织学类型的关系。方法:应用免疫组化技术。结果:p53蛋白胆囊癌阳性表达为59.7%,腺瘤为20%。阳性细胞主要分布在腺瘤的异型增生区;癌旁粘膜p53蛋白阳性表达在异型增生上皮2/4例,单纯增生上皮5/14例,肠化上皮1/2例。腺癌p53蛋白阳性率Ⅰ级48.48%,Ⅱ级90.9%,Ⅲ级71.42%,差异有显著性(P<0.05);Ⅰ级腺癌中,乳头状腺癌阳性率高达66.66%。结论:腺瘤及癌旁粘膜中的异型增生、化生及单纯性增生上皮p53蛋白过度表达,均有发生恶变的潜在可能。
Objective:To study the expression of p53 in 67 gallbladder carcinomas,10 adenomas and adjacent mucosa.Methods:Immunohistochemical technic was used for detection.Results:59.7% of the carcinomas and 20% of the adenomas were positive in staining and the positive cells focus mainly on dysplastic areas of adenoma.In all cases of the adjacent mucosa examined,p53 protein was positive in 2/4 with metaplasia.In the histological studies,p53 positive in well,intermediate and poorly defferentiated adenocarcinoma were 48.48%,90.90%and 71.42% respectively.p53 protein were positive in 66.66% of papillary subtypes,higher than other subtypes in the well defferentiated carcinoma.Conclusion:It suggests that,over expression of p53 protein in dysplasia,metaplasia and hyperplasia of adenoma end mucous membrane of gallbladder carcinoma is potential for malignancy.
出处
《蚌埠医学院学报》
CAS
1997年第1期9-10,共2页
Journal of Bengbu Medical College
关键词
胆囊癌
P53蛋白
免疫组化
gallbladder neoplasms
p53 protein
immunohistochemistry