食管癌脱落细胞β_2微球蛋白检测的诊断价值

Diagnostic value of β 2 microglobulin in exfoliative cells of esophageal cancer

目的：寻找提高食管癌早期诊断准确率的方法。方法：本实验对４１例食管癌患者进行食管拉网，取其脱落细胞，用ＰＡＰ法进行脱落细胞β２微球蛋白（β２ｍ）检测。结果：在４１例食管癌病例中，均发现β２ｍ完全丢失的阴性细胞（即肿瘤细胞），作出正确诊断，无１例假阴性；而常规细胞学方法，４１例中有５例阴性，阳性率仅８７．８％。结论：食管拉网脱落细胞β２ｍ检测有很高的诊断准确率，可作为食管癌诊断、早期诊断和高危人群普查的有效检查方法。

Objective:To evaluate an accurate method for early diagnosis of esophageal cancer.Methods:detection of β 2 microglobulin(β 2m) negative exfoliative cells in 41 cases of esophageal cancer with PAP method.Results:β 2m negative exfoliative cells were considered to be the tumor cells,which were found in all 41 cases of esophageal cancer,wherear,in examination with routine cytological method,the positive rate was only 87.8%.Conclusions:The detection of β 2m negative exfoliated cells is of high diagnostic value in esophageal cancer.