自身免疫性甲状腺疾病树突状细胞和 HLA-DR 抗原的免疫组化研究

IMMUNOHISTOCHEMICAL STUDY ON DENDRITIC CELLS AND HLA DR ANTIGEN IN AUTOIMMUNE THYROID DISEASES

用ＡＢＣ免疫组化法研究桥本甲状腺炎（ＨＴ）和Ｇｒａｖｅｓ病（ＧＤ）患者甲状腺内的Ｓ１００蛋白阳性树突状细胞（ＤＣ）和ＨＬＡＤＲ（ＤＲ）抗原阳性甲状腺上皮细胞（ＴＥＣ）。发现ＨＴ和ＧＤ甲状腺内的Ｓ１００蛋白阳性ＤＣ较正常明显增多，且大多数ＤＣ与ＴＥＣ或浸润淋巴细胞密切接触。ＨＴ和ＧＤ的ＴＥＣ常见ＤＲ抗原异常表达，其主要分布在淋巴细胞浸润区。这说明ＤＣ异常增多、ＴＥＣ异常表达ＤＲ抗原可能与甲状腺自身免疫反应的启动和（或）延续有密切关系。

S 100 protein positive dendritic cells and HLA DR antigen positive thyroid epithelial cells (TEC) in thyroid glands from patients with Hashimoto thyroiditis, or with Graves disease were studied by ABC immunohistochemical method. In Hashimoto thyroiditis and Graves disease, the numbers of S 100 protein positive dendritic cells were much more than those of the controls. The dendritic cells were often seen in close contact with the adjacent TEC or the infiltrating lymphocytes. Most of HLA DR antigen positive TEC were localized to areas harbouring infiltrating lymphocytes. These results suggest that aberrant increase of dendritic cells and aberrant expression of HLA DR antigen on TEC may have a close relation to the initiation and/or maintenance of thyroid autoimmune reaction.