丰富环境训练对低碘大鼠中枢胆碱能神经元的作用初探

ROLE OF VARIED ENVIRONMENT TRAINING ON REGIONAL CHOLINERGIC SYSTEM IN LOW IODINE CRETIN RAT BRAIN

对碘缺乏大鼠从生后２５天起给予丰富环境训练，然后在４０日龄时测定脑重量、蛋白质、脱氧核糖核酸（ＤＮＡ）、乙酰胆碱转移酶（ＣｈＡＴ）、乙酰胆碱酯酶（ＡＣｈＥ）各亚类。结果表明，丰富环境的后天训练对脑的基本构成、细胞数目无明显改善作用。但后天训练可促进大鼠海马、大脑皮层和小脑胆碱能神经元功能活动，尤其是突触部分得以一定程度地改善。

The 25 day old low iodine cretin rats were shifted into a special box, in which there were bridge, cave, ladder, swing, mirror etc. Light music was played one hour four times a day. The protein, DNA, choline acetyltransferase (ChAT) and the molecular forms of acetylcholinesterase (AChE) activities in various brain regions were measured at 40 days of age. The results showed that this special postnatal training did not change the regional protein and DNA of brain. But in hippocampus, cerebral cortex and cerebellum, ChAT, total AChE and nonextractable AChE activities increased. It indicates that function of cholinergic system and cholinergic synaptic compartment may be improved after the training.