上皮钙黏附素在乳腺癌中的表达及其与临床生物学特性的关系

Expression of Epithelial Cadherin in Breast Cancer and Its Relationship with Cancer Biological Characteristics

目的:研究上皮型钙黏附素(E-cadherin)在乳腺癌中的表达及其与临床生物学特性的关系。方法:通过免疫组织化学方法回顾性检测我院78例乳腺癌标本中E-cadherin的表达,分析其与肿瘤临床病理特征间的关系及其与VEGF表达的相关性。结果:E-cadherin在乳腺癌的表达率为52.6%,明显低于癌旁正常乳腺组织的表达,其表达丢失与乳腺癌分化程度、分期及转移密切相关,且和VEGF的高表达呈负相关。结论:E-cadherin在乳腺癌组织呈低表达,其表达丢失与肿瘤分化程度、临床分期及转移有关,E-cadherin的低表达与VEGF表达增强负相关,检测E-cadherin可作为临床评价乳腺癌生物学特性的辅助指标。

Objective： To explore the expression of epithelial cadherin in breast cancer tissue and its relationship with cancer biological characteristics. Methods： Immunohistochemistry was applied to detect the expression of epithelial cadherin protein in 78 cases of breast cancer and 19 cases of adjacent normal breast tissues. Results： Compared with the adjacent normal tissues, the lower expression of epithelial cadherin protein （52.6%） in breast cancer was observed, which was not associated with different tumor types, but had close relationship with histological grades, metastasis and TNM stages. The expression of epithelial cadherin was negatively correlated with VEGF expression in breast cancer. Conclusion： The expression of epithelial cadherin decreased in breast cancer, which was closely related with histological grades, metastasis, TNM stages and the enhanced expression of VEGF. These results suggest that detection of epithelial cadherin expression should be a valuable method for the assessment of the biological behavior of human breast cancer.