防风化学成分的分离与结构鉴定

Isolation and structure identification of chemical constituents from Saposhnikovia divaricata(Turcz.) Schischk

防风乙醇提取物经大孔树脂富集后,采用各种柱色谱法进行分离纯化,从中得到14个化合物,根据理化性质和光谱数据鉴定结构为:防风嘧啶(1),clemiscosin A(2),5-羟基-8-甲氧基补骨脂素(3),亥茅酚苷(4),亥茅酚(5),紫花前胡苷元(6),升麻素苷(7),升麻素(8),5-O-甲基维斯阿米醇苷(9),5-O-甲基维斯阿米醇(10),异紫花前胡苷(11),腺苷(12),胡萝卜苷(13)和β-谷甾醇(14)。其中化合物1为新化合物,化合物2为首次从伞形科植物中分离得到,化合物3为首次从防风中分离得到。

Fourteen compounds were isolated from the ethanol extraction of Saposhnikovia divaricata （Turcz.） Schischk using column chromatographic methods after enrichment by macroporous adsorptive resins. They were identified as fangfengalpyrimidine （1）, clemiscosin A （2）, 5-hydroxy-8- methoxypsoralen （ 3 ）, sec-O-glucosylhamaudol （ 4 ）, hamaudol （ 5 ）, nodakenetin （ 6 ） , prim-O- glucosylcimifugin （ 7 ）, cimifugin （ 8 ）, 4＇-O-β-D-glucosyl-5-O-methylvisamminol （ 9 ）, 5-0- methylvisamminol （ 10）, marmesin （ 11 ）, adenosine （ 12）, daucosterol （13） and β-sitosterol （14） by physico-chemical properties and spectral data. Compound 1 is a new compound. Compounds 2 and 3 were isolated from umbelliferae plants and Saposhnikovia divaricata （Turcz.） Schischk for the first time respectively.