胆管癌的分子生物学进展

Research progression of molecular biology in cholangiocarcinoma

胆管癌早期诊断困难,预后差。越来越多的研究证据表明:多基因、多步骤的遗传性改变,包括癌基因(如bcl-2,c-erbB-2,k-ras)激活、抑癌基因(如p53,DPC4/Smad4,nm23)失活等可能是胆管癌发生的分子基础,胆管癌在其发生发展过程中可使多种肿瘤标志物升高,如MUC,Cal9-9等。

The early diagnosis of cholangiocarcinoma was difficult, and the prognosis of cholangiocarcinoma was poor. With the development of molecular biology in resent years, more and more research evidence about this tumor has been achieved. The changes of multiple inherited characters including oncogenes （such as bcl-2, c-erbB-2, k-ras）activation and anti-oncogene （such as p53, DPC4/ Smad4, nm23） deactivation maybe the molecular basis of genesis of cholangiocarcinoma. Many kind of tumor markers could be increased in the course of genesis and development of cholangiocarcinoma, such as MUC ,Cal9-9 and so on.