可溶性CD40的研究进展

Improvement of soluble CD40

CD40分子是属于肿瘤坏死因子受体(TNFR)超家族的Ⅰ型跨膜糖蛋白,可溶性CD40(sCD40)与膜型CD40(mCD40)共存,并具有与CD40L结合的能力,是CD40-CD40L作用的天然拮抗剂。研究显示健康人血清中存在低水平的sCD40,而肾脏疾病、肝脏疾病、血液病、神经系统疾病等患者血液和体液中异常高表达sCD40,且其水平与病程发展和预后有关,具有重要的临床意义。

CD40, a type Ⅰ transmembrane glycoprotein, belongs to the tumor necrosis factor receptor （TNFR） superfamily. The soluble form of CD40 （sCD40）, which co-exists with the membrane-anchored form （mCD40） in vivo, is able to bind membrane CD40L and is viewed as a natural antagonist of mCD40-CD40L interaction. Low levels of circulating sCD40 have been detected in the blood of normal donors and elevated levels of sCD40 have been reported in the serum and body fluid of patients with kidney disease, liver disease, hematologic malignancies, and nerve system disease, and its clinical significances have been demonstrated, such as its values in diagnosis and prognosis of these disease.