钒对神经行为功能影响的配对分析

Paired-control Study on the Effect of Vanadium on Neurobehavioral Functions

目的探讨长期钒接触对工人神经行为功能的损害作用及表现特征。方法采用WHO推荐的神经行为测试组合对钒接触人群和对照人群做测试,分析时采用配对t检验,对符合标准的106对研究对象进行统计分析。结果①反映积极情绪的有力-好动得分,钒接触组低于对照组,反映消极情绪的紧张-焦虑、抑郁-沮丧、愤怒-敌意、疲劳-惰性、困惑-迷茫得分,钒接触组高于对照组,差异均有统计学意义(P<0.05);②钒接触组视觉保留得分低于对照组(P<0.05);③钒接触组提转敏捷度得分低于对照组(P<0.05);④目标追踪方面,钒接触组正确点数低于对照组,错误点数高于对照组,差异有统计学意义(P<0.05)。结论长期接触五氧化二钒可对工人神经行为功能造成损害,主要表现在消极情绪增加、视觉记忆力下降、运动速度减慢和运动稳定性下降4个方面。

Objective To investigate the change of neurobehavioral functions of workers with long term exposure to vanadium. Methods A total of 106 workers with exposure to vanadium were paired with workers without exposure to vanadium. The WHO-NCTB was employed to assess the neurobehavioral functions. Results The exposure group had lower scores in the domains measuring positive moods and higher scores in the domains measuring negative moods. The exposure group had poorer performance in Santa Ana dexterity, Benton visual retention and pursuit aiming Ⅱ than the control group. Conclusion Exposure to vanadium can adversely affect neurobehavioral functions of workers. Workers exposed to vanadium may show mood disorders, decreased visionmemory, and declined motor speed and accuracy.