缺血性脑血管病与颅内动脉粥样硬化性狭窄及危险因素的关系

Relationship between ischemic stroke and internal carotidal artery atherosclerotic stenosis along with risk factors

目的:研究缺血性脑血管病与颅内动脉粥样硬化性狭窄及危险因素的关系。方法:对125例缺血性脑血管病患者(缺血性脑血管病组)及120例非梗死患者和正常体检者(对照组)进行经颅多普勒超声和血脂、血糖检查。结果:缺血性脑血管病组颅内动脉粥样硬化性狭窄检出率(38.4%)与对照组(10.8%)比较差异有显著性(P<0.01)。缺血性脑血管病组颅内动脉粥样硬化性狭窄的分布依次为大脑中动脉(70.8%)、椎基底动脉(37.5%)、大脑前动脉(31.3%)、颈内动脉末段(10.4%)。有高血压、糖尿病、冠心病、卒中家族史的缺血性脑血管病患者容易发生颅内动脉狭窄,其OR值分别为2.56、3.46、4.12、5.20(均P<0.05)。缺血性脑血管病组高密度脂蛋白(1.09±0.32)mmol/L比对照组(1.33±0.40)mmol/L低(P<0.05)。结论:颅内动脉粥样硬化性狭窄与缺血性脑血管病发生有密切关系,颅内动脉粥样硬化性狭窄的危险因素有高血压、糖尿病、冠心病、卒中家族史,保护因素有高密度脂蛋白。

Objective：To explore the relationship between ischemic stroke and internal carotidal artery atherosclerotic stenosis along with risk factors. Methods： 125 patients with ischemic stroke （CI group） and 120 normal control subjects （Controls group） were examined with color Doppler sonography, blood lipid and blood glucose. Results： In CI group, the rate of atherosclerotic stenosis in carotidal artery was 38.4% ; in Controls group, the rate was 10.8%. There were significantly different between CI group and Controls group （P 〈 0.01 ）. In CI group, the distribution of carotidal artery atherosclerotic stenosis is in turns of middle cerebral artery （70. 8% ）, vertebrails artery （37.5 % ）, anterior cerebral artery （31.3 % ）, end portion of internal carotidal artery （10.4%）. The ischemic stroke patients with hypertension, diabetes, coronary heart disease and family history of stroke. Conclusions ： Ischemic stroke is closely related to internal carotidal artery atherosclerotic stenosis. The risk factor of internal carotidal artery atherosclerotic stenosis is hypertension, diabetes, coronary heart disease and family history of stroke, the protect factor was high density lipoprotein story of stroke were prone to internal carotidal artery atherosclerotic stenosis, OR value were 2.56,3.46,4.12,5.20 respectively. （ P 〈 0.05 ） High density lipoprotein of CI Group （ 1.09 ±0.32 ） mmol/L were lower than that of Controls group （ 1.33 ±0.40） mmol/L. （ P 〈 0.05 ） .