注射用硫酸头孢噻利与头孢他啶治疗急性细菌性感染随机治疗临床研究

Randomized controlled clinical trial of cefoselis hydrogen sulfate injection versus ceftazidime in the treatment of acute bacterial infection

目的研究注射用头孢噻利治疗急性细菌性呼吸道和泌尿道感染的有效性和安全性。方法用双盲随机平行对照试验方法,以头孢他啶作为对照药。头孢噻利（127例）和头孢他啶（125例）均为每日2.0-4.0g,分2次静滴,疗程为7-14天。结果治疗后,2组总有效率分别为94.49%,92.00%;细菌清除率分别为96.26%,96.23%。药物不良反应发生率分别为5.43%,3.88%。结论注射用头孢噻利治疗急性细菌性呼吸道和泌尿道感染有效、安全,优于头孢他啶。

Objective To evaluate the clinical efficacy and safety and adverse drug reaction of injective Cefoselis in the treatment of acute respiratory and urinary bacteria infection, including respiratory tract infection and urinary tract infection. Methods A randomized controlled open clinical trial was carried out. Ceftazidime as a controlled drug. Cefoselis （ trial, 127 cases） and eeftazidime （ control, 125 cases） was 2 - 4g every 12 hours by intravenous infusion respectively. The course of treatment was 7 - 14 days. Results The clinical total effective rate of cefoselis group was 94.49% ; the bacterial clearance rate were 96.26%. While those of ceftazidime group were 92.00% ,and 96.23 % respectively. The incidence of adverse reaction of cefoselis group was 5.43% , those of ceftazidime group was 3.88%. Conclusion Cefoselis hydrogen sulfate injection is a kind of effective and anti - bacterial drug.