异丙酚全麻下瑞芬太尼在手术患者的药代动力学

Pharmacokinetics of remifentanil under general anesthesia with propofol in operation patients

目的研究瑞芬太尼(麻醉药)复合异丙酚靶控输注静脉全麻的临床药代动力学。方法选择24例靶控输注异丙酚全麻手术患者,以不同速度0.50,0.75,1.00μg·(kg·min)-1输注瑞芬太尼,取桡动脉血浆,用高效液相色谱-紫外法检测瑞芬太尼浓度,用DAS计算药代动力学参数。结果瑞芬太尼符合二室模型,3组患者的t1/2α、t1/2β、V1、V、CL比较无显著性差异(P>0.05),AUC(0-∞)、V、t1/2β和CL的RSD分别为33.42%,67.38%,51.22%和68.10%。结论瑞芬太尼不同输注速率对药代动力学无明显影响,但应注意个体化给药。

Objective To investigate the pharraacokinetics profile of reraifentanil in operation patients under general anesthesia with target controlled infusion of propofol. Methods Twenty - four patients were anesthesized with target controlled infusion of propofol were received reraifentanil by constant - rate infusion of 0.50,0.75 and 1. 00 μg·kg·min^-1 （ group Ⅰ, Ⅱ, Ⅲ, n = 8 ） for 20 min respectively . Remifentanil concentrations were determined by high performance liquid chromatography with ultraviolet detection （HPLC -UV）. Pharraacokinetic analysis was performed using DAS program. Results Pharmacokintics of reraifentanil in three groups were best described by a two compartment pharmacokinetic model. The pharmacokinetic parameters were similar in three groups. The RSD of AUC〈0-∞〉 ,V,t1/2β and CL were 33.42%, 67.38% ,51.22% and 68.10% respectively. Conclusion The constant -rate infusion had not influence on the pharmacokinetics of remifentanil （P 〉 0.05 ）. The dosage of reraifentanil should be prescribed individually.