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对口服结肠定位给药系统的认识及审评实践 被引量：2

Discussion some question on the oral colon-specific drug delivery system in drug development and evaluation
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摘要 本文系统介绍了开发口服结肠定位给药系统必要性,其主要类型和特点,并结合此类药品开发中存在的问题进行探讨。
作者 赵明 熊燃 张哲峰 杨进波 赵德恒
机构地区 国家食品药品监督管理局药品审评中心
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2006年第6期475-479,共5页 The Chinese Journal of Clinical Pharmacology
关键词 结肠定位给药系统 审评
分类号 R954 [医药卫生—药学]
  • 相关文献

参考文献21

  • 1Watts PJ,Illum L.Colonic drug delivery[J].Drug Dev Int Pharm,1997;23:893 -913.
  • 2莫韫,张钧寿.结肠靶向给药系统研究进展[J].中国新药杂志,1999,8(6):368-371. 被引量：24
  • 3Bai JP,Chang LL,Guo JH.Targeting of peptide and protein drugs to specific sites in the oral route[J].Crit Rev Ther Drug Carrier Syst,1995; 12:339-346.
  • 4Roug N,Buri E,Doelker E.Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery[J].Int J Pharm,1996;136:117.
  • 5Mooter GVD,Maris B,Samyn C,et al.Use of azo polymers for colon -specific drug delivery[J].J Pharm Sci,1997 ;86:1312.
  • 6Mackay M,Thomlinson E.Colonic delivery of therapeutic peptides and proteins[A].Bieck PR.Colonic Drug Absorption and Metabolism[M].New York,1993:159-176.
  • 7张正全,陆彬.口服结肠定位给药系统新进展[J].中国药学杂志,2000,35(4):221-223. 被引量：41
  • 8Tozaki H,Komoike J,Tada C,et al.Chitosan capsules for colon-specific drug delivery:impr-ovement of insulin absorption from the rat colon[J].J Pharm Sci,1997 ;86:1016-1028.
  • 9Marvola M,Nykamen P,Rautio S,et al.Enteric polymers as binders and coating materials in multiple unit site-specific drug delivery systems[J].Eur J Pharm Sci,1999 ;7:259-271.
  • 10Muraoka M,Kimura G,Zhaopeng H,et al.Ulcerative colitiscolon delivery of 5-aminosalicylic acid[J].Nippon Rinsho,1998 ;56:788 -797.

二级参考文献23

  • 1GangCheng,FengAn,Mei-JuanZou,JinSun,Xiu-HuaHao,Yun-XiaHe.Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid[J].World Journal of Gastroenterology,2004,10(12):1769-1774. 被引量：6
  • 2李国锋,陈建海,刘立捷,郭丹,晏媛,许重远,陈志良.结肠菌群触发型5-氨基水杨酸壳聚糖胶囊大鼠体内的吸收与分布研究[J].第一军医大学学报,2003,23(5):431-434. 被引量：14
  • 3Bai JP,Chang LL,Guo JH.Targeting of peptide and protein drugs to specific sites in the oral route[J].Crit Rev Ther Drug Carrier Syst,1995,12(4)∶339-346.
  • 4Watts PJ,Illum L.Colonic drug delivery[J].Drug Dev Int Pharm,1997,23(9)∶893-913.
  • 5Tozaki H,Komoike J,Tada C,et al.Chitosan capsules for colonspecific drug delivery:improvement of insulin absorption from the rat colon[J].J Pharm Sci,1997,86 (9)∶1016-1028.
  • 6Marvola M,Nykanen P,Rautio S,et al.Enteric polymers as binders and coating materials in multiple unit site-specific drug delivery systems[J].Eur J Pharm Sci,1999,7(3)∶259-271.
  • 7Muraoka M,Kimura G,Zhaopeng H,et al.Ulcerative colitiscolon delivery of 5-aminosalicylic acid[J].Nippon Rinsho,1998,56(3)∶788-797.
  • 8Takaya T,Niwa K,Muraoka M,et al.Importance of dissolution process on systemic availability of drugs delivered by colon delivery system[J].J Controlled Release,1998,50∶111-122.
  • 9Gupta VK,Beckert TE,Price JC,et al.A novel pH- and timebased multi-unit potential colonic drug delivery system.I.Development[J].Int J Pharm,2001,213∶83-91.
  • 10Li SP,Feld KM.The effect of polymer coating systems on the preparation,tableting,and dissolution properties of sustained-release drug pellets[J].Drug Dev Ind Pharm,1997,23(7)∶623-631.

共引文献121

同被引文献6

  • 1ZHANG Hong,ZHAO ChenGuang,ZHAO YunHui,TANG GongWen & YUAN XiaoYan School of Materials Science and Engineering,and Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300072,China.Electrospinning of ultrafine core/shell fibers for biomedical applications[J].Science China Chemistry,2010,53(6):1246-1254. 被引量：7
  • 2PRAKASH A, MARKHAM A. Oral delayed - release mesalazine [ J ]. Drugs, 1999, 57 (3) : 383 - 408.
  • 3FUKUI E, MIYAMURA N, KOBAYASHI M. An in vitro investigation of the suitability of press-coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting [J]. Journal of Controlled Release, 2001, (70):97- 107.
  • 4FALLINGBORG J, CHRISTENSEN LA, JACOBSEN BA, et al. Very low intraluminal colonic pH in patients with active ulcerative colitis[J ]. Digestive Diseases and Science, 1993, 38(11) : 1989 - 1993.
  • 5邵堃,黄容琴,蒋晨,蒋新国.脑靶向药物纳米递释系统[J].东南大学学报（医学版）,2011,30(1):169-184. 被引量：6
  • 6傅崇东,徐惠南,张瑜.5-氨基水杨酸结肠定位给药时控微丸的制备与体外释放[J].药学学报,2000,35(5):389-393. 被引量：36

引证文献2

二级引证文献6

中国临床药理学杂志
2006年 第6期

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