法呢基焦磷酸(FPP)的生物合成及其分子调控

The Biosynthetic Pathway and Molecular Regulation of Farnesyl Diphosphate(FPP)

法呢基焦磷酸合酶作为异戊二烯途径中的重要调节酶,是许多萜类物质的合成前体。FPS的cDNA克隆在许多生物体中也已得到了分离并进行了表达特性研究。从FPP的生物合成途径入手,对FPP生物学特性、FPS酶基因调控的相关信息进行了综述,同时对FPS在基因工程方面的应用进行了展望。

In the isoprenoid biosynthesis pathway,famesyl diphosphate synthase （FPS,EC2. 5. 1. 1/EC2. 5. 1. 10） catalyzes two consecutive condensations of isopentenyl diphosphate with dimethylallyl diphosphate,forming geranyl diphosphate （FPP）which is a common precursor for the biosynthesis of sterols,dolichols,mitochondrial electron transfer chain components,prenylated proteins and a wide range of secondary sesquiterpenoids. Recently,cDNAs encoding FPS had been isolated from a number of plant species. In the paper,the biosythasis pathway and molecular regulation of farnesyl diphosphate were reviewed,and progress of FPS applied in genetic engineering was also prospected.