细胞色素P450的基因多态性与药物代谢

Genetic polymorphism of cytochrome P450 and drug metabolism

细胞色素P450(cytochrome P450,CYP)是重要的药物代谢酶,参与催化多种内源和外源化合物,特别是多种临床药物的生物转化。CYP存在广泛的基因多态性和表型多态性,使其对于各种化合物的代谢存在统计学个体差异。核受体是配体依赖性转录因子超家族,与药物代谢过程中的基因表达调控密切相关,被外源物质活化后诱导或抑制CYP基因的表达。现综述CYP与药物代谢、CYP的基因多态性、CYP表达的诱导机制、核受体及其配体诱导CYP表达及近年研究CYP450的各种实验方法。

Cytochrome P450 （CYP） is a family of the body＇s more powerful detox enzymes that involves in the biotransformation of various endogenous and exogenous compounds including clinical drugs. Genetic and phenotypic polymorphism of CYP results in the individual differences of xenobiotic metabolisms. Nuclear receptors belong to a superfamily of ligand-activated transcription factors, which are involved in regulating gene expression in drug metabolic processes by inducing or inhibiting the expression of CYP. This article reviews CYP and drug metabolic, genetic polymorphism of CYP, inducing mechanism of CYP expression, nuclear receptors with their ligands inducing the expression of CYP and research methods of CYP in passing years.