三类白细胞核孔筛滤试验的双参数模型

A Two-Parameter Model for Three Types of Unclepore Filtration of Leukocytes

白细胞核孔筛滤试验是估计白细胞变形性的主要方法之一．我们对这一试验的三类情形提出了生物流体力学模型，这三类情形是：（i）自身重力过滤；（ii）恒压过滤；（iii）恒流量过滤．在以前的模型中，细胞阻力被假定为一常数，而在本文中，我们考虑细胞阻力时，同时顾及了驱动压力和白细胞个体变形性差异的影响．而且，我们在Moessmer实验基础上，对多形核粒性白细胞通过核孔的时间假定了一个概率分布函数．最后我们得到了以上三种情形的数值解，第一种情形的解与实验结果的对比是令人满意的．文中的双参数，A和B，代表了不同压力下白细胞变形性的不同．

Microporc filtration of leukocytes is one of the main methods for evaluatingleukocytesl deformability. Here a biofluid mechanical model was proposed forthree cases: (i) filtration under gravity: (n)constant pressure filtrationl (iii)constant flow rate filtration in previous mode1s, constant blood cell resistancewas assumed. In this paper, when evaluating the filter resistance to leukocytes,not only the effect of the change in the driving pressure but also the differencein the deformability of individual leukocytes are taken into consideration.Moreover based on Moessmer I S e-cper imental resul t s,a probabil ity distr ibution functionfor the transit time of polymorphonuclear cells (PMNn) through the filter isassumed. Finally, numerical curves are obtained for the above three types of filtrat ion and the comparison between the theoretical and experimental results ofPMNs for case (i) turns out to be satisfactory The two parameters in the model, A and B represnet leukocytes' deformability under low alld high pressuresr expect ive I y.