染色体乘客复合体对细胞有丝分裂的调控作用

Role of chromosomal passenger complex in cell mitosis

染色体乘客复合体(CPC)是近年来处于细胞有丝分裂调控研究热点的一组蛋白分子,主要由Aurora B激酶、着丝粒中心蛋白(INCENP)、Survivin及Borealin/DasarB等蛋白分子组成。研究证实CPC在有丝分裂过程中扮演了重要的角色,涉及纺锤体形成、染色体排列、姊妹染色单体分离、纺锤体检查点信号及胞质分裂等多种重要功能的调节。本文重点阐述了CPC各组成蛋白功能特点、相互作用及对纺锤体检查点蛋白和微管蛋白的调节等方面的最新研究进展,同时阐明CPC组成蛋白作为抗癌药物研制靶标的潜在应用价值。

Chromosomal passenger complex （CPC） is a group of proteins that take part in coordinating the chromosomal and cytoskeletal events of mitosis. This complex includes at least four members： Aurora B, Survivin, INCENP, Borealin. The localization, dynamics and functions of these proteins are interdependent. CPC involved in several processes of mitosis, such as assembly of a stable bipolar spindle, chromosome segregation and the completion of cytokinesis. In this review, we focused on the functions and interaction of CPC proteins, introduced the regulation of the CPC to spindle assembly checkpoint and microtubule, and discussed the prospect of the CPC proteins as targets for anticancer therapy.