摘要
目的:采用高效液相法同时测定米格来宁片中安替比林和咖啡因的含量。方法:以C18化学键合硅胶为固定相,以甲醇-水(42:58)为流动相,检测波长为273nm。结果:安替比林平均回收率为100.30.4,RSD=0.52(n=6);咖啡因为99.5%,RSD=0.73(n=6)。安替比林在98.2~147mg范围内;咖啡因在9.99-15.0mg范围内,进样量与峰面积值呈良好的线性关系。结论;方法简便、快速、结果准确。
Objective:To determine the content of Antipyrine and Caffeine in Migelaining Tablets by HPLC. Method:To take Cls chemical bonded silica gel as solid phase,methanol-water(42 : 58)as mobile phase and UV detecting wavelength is at 273nm. Result:The average recovery of Antipyrine is 100. 3% ,RSD:0. 52(n=6). The average recovery of Caffeine is 99.5% ,RSD: 0.73 (n= 6). There is a good linear relationship between the concentration and peak area in the range of Antipyrine 98.2-147mg and caffeine 9.99-15.0mg. Conclusion:This method is accurate,rapid and simple.
出处
《中国药品标准》
CAS
2007年第1期41-42,共2页
Drug Standards of China