离子液体介质中Knoevenagel缩合反应研究

Investigation of Knoevenagel condensation in hydrophilic ionic liquid

以亲水性离子液体1-丁基-3-甲基咪唑对甲基苯磺酸盐作反应介质,醋酸铵为催化剂,研究了不同的芳香醛和脂肪醛与活泼亚甲基类化合物氰乙酸乙酯进行Knoevenagel缩合反应.反应产物经熔点、核磁共振谱、GS-MS、气相色谱等表征.结果表明,该方法产率高,速度快,选择性好,所使用的离子液体能够重复使用.

The knoevenagel condensation of carbonyl substrates with active methylene compound was investigated using ammonium acetate as catalyst in presence of ionic liquid [ bmim] [ p-CH3C6H4SO3 ]. Yields for each reaction were moderate to excellent. The ionic liquid was successfully recycled for reuse. The catalytic activity of different medium was compared.