血脂康胶囊中化学成分的研究

Chemical constituents of Xuezhikang Capsula

目的研究血脂康胶囊中的化学成分。方法通过硅胶、Sephadex LH-20柱色谱,结合重结晶技术,从血脂康胶囊中分离得到9个化合物,经理化性质鉴定、波谱解析以及与已知化合物对照,鉴定其结构。结果分别鉴定为脱水莫纳可林K(Ⅰ)、豆甾-5,22-二烯-3β-醇(Ⅱ)、莫纳可林K(Ⅲ)、3β-羟基-5α,8β-环二氧麦角甾-6,22-二烯(Ⅴ)、N-[1-(四氢-5-氧代呋喃-2)-乙基]乙酰唑胺(Ⅵ)、大豆苷元(Ⅶ)、黄豆黄素(Ⅷ)、染料木素(Ⅸ)、赤藓醇(Ⅹ)。结论以上化合物除Ⅰ、Ⅲ外,均首次从血脂康胶囊中分离得到。化合物Ⅵ为新的天然产物。

Objective To study the chemical constituents of Xuezhikang Capsula. Methods Sihca gel and Sephadex LH-20 were used to isolate the compounds, EI, FAB-MS, and 1 D and 2 D-NMR were used to identify the obtained compounds. Results Nine compounds were obtained from the capsula, they were charactered as dehydromonacolin K （ Ⅰ ）, stigmasta-5, 22-dien-3β-ol （ Ⅱ ）, monacolin K （Ⅲ）, 3β- hydroxy-5α, 8β epidioxyergostera-6, 22-diene （ Ⅴ ）, N- [1- （tetrahydro-5-oxofuran-2-yl）-ethyl] acetamide （Ⅵ）, 7, 4′-dihydroxy-isoflavone （Ⅶ）, 7, 4′-dihydroxyisoflavone-6-methoxyisoflavone （Ⅷ）, 5, 7, 4′-trihydroxyiso-flavone （Ⅸ）, erythritol （ Ⅹ ）. Conclusion They are all obtained from the capsula except Ⅰ and Ⅲ for the first time, among them Ⅵ is a new natural compound.