摘要
目的研究地龙提取物的抗凝血作用。方法观察地龙提取物对小鼠凝血、出血时间和家兔离体血浆复钙时间的影响,测定提取物中游离氨基酸的量。结果地龙提取物能延长小鼠凝血、出血时间和家兔离体血浆复钙时间。游离氨基酸测定结果表明,提取物中含有丰富的氨基酸。结论地龙提取物所含的游离氨基酸可能是其抗凝血作用的有效成分。
Objective To study the anticoagulant effects of Pheretirna extracts and analyze the effective constituents. Methods Antithrombotic effects of Pheretirna extracts were observed by determining the coagulation time, bleeding time of mice and the recalcification time of rabbit plasma in vitro, meanwhile the content of free amino acid in the extracts were determined. Results Pheretima extracts could prolong the coagulation time, bleeding time of mice, and the recalcification time of rabbit plasma in vitro. The content of free amino acid was rich in Pheretima extracts. Conclusion Free amino acid in Pheretima extracts may be the main anticoagulant effective constituents.
出处
《中草药》
CAS
CSCD
北大核心
2007年第5期733-735,共3页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金杰出青年项目(30225049)
关键词
地龙
抗凝血作用
氨基酸
Pheretima
anticoagulant effects
amino acid
