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胰岛素样生长因子-Ⅰ的生物学功能及在畜牧业中的应用前景

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摘要 下丘脑—GH—IGF—Ⅰ轴是一个重要的体内分泌代谢轴，对生长发育的调控贯穿动物的整个生命过程。自Sallmon和Daughaday首次发现并报道这一与生长激素密切相关的因子以来，人们对胰岛素样生长因子-Ⅰ（IGF—Ⅰ）的研究方兴未艾，不仅对胰岛素生长因子（IGFS），而且对IGF受体（IGFR）、IGF结合蛋白（IGFBP）以及IGFBP酶也越来越关注。而大量研究表明，出生后生长激素（GH）对动物生长的调节作用是由IGF—Ⅰ介导的，体内外试验也证明，IGF—Ⅰ具有促进组织生长和参与组织代谢活动的作用。而重组IGF—Ⅰ生物制品的出现。又为其在疾病诊断和治疗方面的研究开辟更为广阔的空间。
作者 和玉丹
机构地区 浙江大学饲料科学研究所
出处 《饲料工业》 2007年第10期45-47,共3页 Feed Industry
关键词 胰岛素样生长因子-Ⅰ 生物学功能 畜牧业 IGFBP 胰岛素生长因子 应用 生长激素 动物生长
分类号 S816.7 [农业科学—饲料科学]
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参考文献32

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饲料工业
2007年 第10期

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