氯诺昔康复合曲马多在口腔颌面部手术术后镇痛中的平衡应用

Balance Analgesia of Lornoxicam Combined with Tramadol for Postoperation of Oral Cavity,Jaw and Face

目的：观察静脉氯诺昔康与曲马多在口腔颌面部手术后镇痛的临床效果及不良反应。方法：ASAⅠ-Ⅱ级60例择期行口腔颌面部手术病人,随机分为两组,氯诺昔康组（L组）和曲马多组（T组）,每组30例。L组：氯诺昔康32mg＋曲马多400mg＋氟哌利多5mg;T组：曲马多800mg＋氟哌利多5mg,均以生理盐水配置100ml药袋,给予负荷剂量4ml后连接ACE Medical镇痛泵进行自控镇痛（PCA）。术后行2、8、20、44 h VAS评分,并对有效按压次数、用药量及不良反应发生情况进行了观察比较。结果：两组VAS评分、有效按压次数、用药量均无显著差异（P〉0.05）,不良反应发生率T组明显高于L组。结论：氯诺昔康与曲马多联合应用于口腔颌面部手术的术后镇痛与曲马多单独应用效果相当,但不良反应发生率明显低于后者,是一种更安全、有效的平衡镇痛方法。

Objective： To study the balance analgesia efficacy and side effects of lornoxicam and tramadol postoperation of oral or jaw and face. Methods： Sixty ASA Ⅰ-Ⅱ patients were randomly divided into two groups, lornoxicam group（group L）and tramadol group（group T）. Lornoxicam group（n= 30）received lornoxicam 32mg ＋tramadol 400mg ＋dropridol 5mg. Tramadol group （n= 30）received tramadol 800mg＋ droperidol 5mg. The visual analgesia scale （VAS） was assessed at 2,8,20,44hours after operation. Drugs dose and availability press times were compared and the side effects such as dizzy, nausea were observed. Results： VAS and drugs dose were no significantly difference in two groups（P〉0. 05）. But side-effects were significantly increased in group T compared with those in group L. Conclusion： The analgesia efficacy of lornoxicam combined with tramadol is same as tramadol after oral or jaw and face operation, but side effects significantly increase in group T, group L is more safe and handly.